Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis
Trop-2 is a transmembrane signal transducer that can induce cancer growth.Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region, between residues R87 and T88.Molecular modeling indicated that this cleavage induces a profound rearrange